Motorcycles can become unstable when operating at high speeds and at high cornering levels. For example, they can exhibit an oscillation at the rear wheel commonly known as “weave.” A system and method is provided which utilizes a high-fidelity computer simulation model of a 2- or 3-wheel motorcycle to predict operating states such as yaw rate, lateral acceleration and roll angle for a stable motorcycle at a given speed and steer angle. The operating state of a physical motorcycle can be measured and compared to that of the model at every instant in time to determine if the operating state of the physical motorcycle differs from that of the simulation model in such a way as to indicate loss of stability. The nature of that difference can then be used to intervene in the operation of the motorcycle independent of driver actions by application of brakes, modulating the engine torque or applying torques to urge the steering system in a corrective direction. Thus by comparing the physical response of the motorcycle to that of the computer model in an on-board controller these interventions can be applied at a time and intensity to stabilize the motorcycle and prevent a loss of control.