- Patent Title: Trifunctional T cell-antigen coupler and methods and uses thereof
-
Application No.: US15117173Application Date: 2015-02-06
-
Publication No.: US10435453B2Publication Date: 2019-10-08
- Inventor: Jonathan Bramson , Christopher W. Helsen , Galina Denisova , Rajanish Giri , Kenneth Anthony Mwawasi
- Applicant: MCMASTER UNIVERSITY
- Applicant Address: CA Hamilton, Ontario
- Assignee: MCMASTER UNIVERSITY
- Current Assignee: MCMASTER UNIVERSITY
- Current Assignee Address: CA Hamilton, Ontario
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/CA2015/000068 WO 20150206
- International Announcement: WO2015/117229 WO 20150813
- Main IPC: C07K14/73
- IPC: C07K14/73 ; C07K16/28 ; A61K35/17 ; C07K14/725 ; C07K16/32
Abstract:
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
Public/Granted literature
- US20160368964A1 TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF Public/Granted day:2016-12-22
Information query
