Invention Grant
- Patent Title: Method of using antibody polypeptides that antagonize CD40 to treat IBD
-
Application No.: US15118279Application Date: 2015-03-09
-
Publication No.: US10435475B2Publication Date: 2019-10-08
- Inventor: Marek Honczarenko , Vaishali Shah , Xiaoni Liu , Wendy L. Trigona , Rong Shi , Suzanne J. Suchard , Karen D. Price , Linda M. Gustavson
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Drinker Biddle & Reath LLP
- International Application: PCT/US2015/019506 WO 20150309
- International Announcement: WO2015/134988 WO 20150911
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; A61K47/60 ; A61K39/00
Abstract:
A method of treating an inflammatory bowel disease is provided. The method comprises administration of an antibody polypeptide that specifically binds a novel epitope of human CD40. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides may be fusions of a domain antibody (dAb) comprising a single VL or VH domain and an Fc domain.
Public/Granted literature
- US20160355596A1 METHOD OF USING ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40 TO TREAT IBD Public/Granted day:2016-12-08
Information query
