Invention Grant
- Patent Title: Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
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Application No.: US15847283Application Date: 2017-12-19
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Publication No.: US10435690B2Publication Date: 2019-10-08
- Inventor: Joseph Collard , Olga Khorkova Sherman , Carlos Coito , Gang Shen
- Applicant: CuRNA, Inc.
- Applicant Address: US FL Miami
- Assignee: CuRNA, Inc.
- Current Assignee: CuRNA, Inc.
- Current Assignee Address: US FL Miami
- Agency: CuRNA, Inc.
- Agent Monte E. Browder
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/7088 ; C12N15/10 ; G01N33/53
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Alpha-L-Iduronidase (IDUA), in particular, by targeting natural antisense polynucleotides of Alpha-L-Iduronidase (IDUA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IDUA.
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