Invention Grant
- Patent Title: Method to estimate age of individual based on epigenetic markers in biological sample
-
Application No.: US14119145Application Date: 2012-05-18
-
Publication No.: US10435743B2Publication Date: 2019-10-08
- Inventor: Eric Vilain , Sven Bocklandt , Steve Horvath , Janet Sinsheimer
- Applicant: Eric Vilain , Sven Bocklandt , Steve Horvath , Janet Sinsheimer
- Applicant Address: US CA Oakland
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Agency: Gates & Cooper LLP
- International Application: PCT/US2012/038552 WO 20120518
- International Announcement: WO2012/162139 WO 20121129
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/6876 ; C12Q1/6883
Abstract:
The invention provides methods and materials that use observation of DNA characteristics to obtain information relating to the age of individuals. The instant disclosure identifies 88 sites in or near 80 genes for which the degree of cytosine methylation in epithelial and/or white blood cells is significantly correlated with age. In illustrative embodiments of the invention, cytosine methylation patterns the promoters of the EDARADD, TOMILI, and NPTX2 genes are used to predict the age of an individual with a high degree of accuracy.
Public/Granted literature
- US20140228231A1 METHOD TO ESTIMATE AGE OF INDIVIDUAL BASED ON EPIGENETIC MARKERS IN BIOLOGICAL SAMPLE Public/Granted day:2014-08-14
Information query
