Invention Grant
- Patent Title: Combination of biomarkers for detecting and evaluating a hepatic fibrosis
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Application No.: US15488614Application Date: 2017-04-17
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Publication No.: US10435744B2Publication Date: 2019-10-08
- Inventor: Bénédicte Watelet , Tarik Asselah , Ivan Bieche , Isabelle Catherine Batxelli , Nathalie Jullian , Michel Vidaud , Patrick Marcellin , Daniel Laune , Mohammad Afshar , Eve Laure Mathieu
- Applicant: BIO-RAD EUROPE GMBH , ARIANA PHARMACEUTICALS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Applicant Address: CH Basel FR Paris FR Paris FR Paris FR Paris
- Assignee: BIO-RAD EUROPE GMBH,ARIANA PHARMACEUTICALS,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee: BIO-RAD EUROPE GMBH,ARIANA PHARMACEUTICALS,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee Address: CH Basel FR Paris FR Paris FR Paris FR Paris
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: FR1151022 20110209
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/576 ; C12Q1/6876 ; C12Q1/6883 ; C12Q1/70
Abstract:
The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.
Public/Granted literature
- US20170283871A1 COMBINATION OF BIOMARKERS FOR DETECTING AND EVALUATING A HEPATIC FIBROSIS Public/Granted day:2017-10-05
Information query
