Disclosed are a method and a device for controlling refrigerant in an air conditioning system. The method includes: S1: comparing a superheat degree of each outdoor unit with an average superheat degree; S2: if the superheat degree of a present outdoor unit is higher than the average superheat degree, and a first different between the superheat degree of the present outdoor unit and the average superheat degree is greater than a present value, increasing a refrigerant amount entered into the present outdoor unit; and S3: if the superheat degree of the present outdoor unit is lower than the average superheat degree, and a second different between the average superheat degree and the superheat degree of the present outdoor unit is greater than the present value, decreasing the refrigerant amount entered into the present outdoor unit. Therefore, the refrigerant amount entered into each outdoor unit is adjusted from systemic overall perspective.