Systems and methods for providing a partitioned interconnect slot for inter-processor operation. In an illustrative, non-limiting embodiment, an Information Handling System (IHS) may include: a processor comprising a first core and a second core; and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution, cause the IHS to enable an Input/Output (I/O) device to communicate directly with the first core and the second core utilizing a single interconnect slot.