A website acceleration method and system based on a content delivery network. The method includes: detecting a resource structure of a website and acquiring a domain name and resource of the website; monitoring operation data of the website, acquiring a user individual IP distribution of an accessed website, analyzing and acquiring a region to which the user individual IP belongs, a network operator type and resource accessed by the user individual IP; connecting an accelerated domain name provided by each CDN acceleration service provider, and establishing a comparison task of comparing each CDN acceleration service provider to the acceleration effect of the website according to the operation data of the website; acquiring the optimal accelerated domain name of the website in each region, each network operator and different types of resource according to test result of the comparison task of the acceleration effect; and selecting the optimal CDN acceleration service provider corresponding to each resource according to the optimal accelerated domain name. The present invention enables a website to select a CDN acceleration service according to the website's own practical situation, achieving an optimal acceleration effect in each national region, and reasonably controlling usage costs.