Front-end architectures for multiple antennas. In some embodiments, a front-end architecture for wireless application can include a first mid-band amplifier system configured to amplify transmit and receive signals in a first mid-band. The front-end architecture can further include a second mid-band amplifier system configured to amplify at least a transmit signal in a second mid-band, such that the front-end architecture is capable of simultaneous uplink operations in the first mid-band and the second mid-band.