Systems and methods for presenting targeted digital on-screen graphics are described. A content originator, such as an advertiser or media network operator, may specify targeted segments and/or targeted digital on-screen graphics to be presented to one or more viewers of an available audience. The expected presentation of a digital on-screen graphic on a content presentation device associated with targeted segments may be detected. A target digital on-screen graphic may be transmitted or otherwise made available to the content presentation device. The targeted digital on-screen graphic may be displayed instead of or overlaying at least a portion of the original digital on-screen graphic, such that all or a portion of the original digital on-screen graphic is substituted by the target digital on-screen graphic.