An electronic device may include wireless communications circuitry, control circuitry, and sensor circuitry. The wireless communications circuitry may include amplifier circuitry that amplifies radio-frequency signals using on a bias voltage to generate amplified radio-frequency signals transmitted over an antenna. Power supply circuitry may generate the bias voltage based on an envelope mapping setting and an envelope signal associated with the radio-frequency signals. The sensor circuitry may generate sensor data that characterizes the performance of the wireless communications circuitry and provide the sensor data to the control circuitry. The control circuitry may use the provided sensor data to generate control signals for the power supply circuitry. The control signals may adjust the envelope mapping setting of the power supply circuitry.