A thermoelectric module for cooling a heat source includes multiple major sections, each major section including multiple minor sections. Each minor section includes one or more thermoelectric cooler (TEC) units including P-type and N-type semiconductors. Each major section also includes a single output terminal commonly connected to the minor sections, where the output terminal is configured to provide a same reference voltage signal to each of the minor sections. Each major section also comprises multiple input terminals, where each input terminal is separately connected to one of the minor sections and each input terminal is configured to provide a separate input voltage signal to each of the minor sections. The module also comprises a controller configured to independently control each reference voltage signal applied to each major section, and independently control each input voltage signal applied to each input terminal of each minor section within each major section.