A patient mobility system for early patient ambulation. The system includes a patient support apparatus comprising a patient support surface supported by a base adapted to rest upon a floor surface. An ambulation device is removably coupled to the patient support apparatus and comprises a barrier. In a coupled configuration, the ambulation device is supported off of the floor surface and the barrier prevents egress by being adjacent to a side of said patient support surface and having a height sufficient to at least partially extend above the patient support surface. In a decoupled configuration, the ambulation device engages the floor surface and provides support to the patient during ambulation away from the patient support apparatus. The barrier may comprise articulating members configured to articulate between a barrier configuration in the coupled configuration, and a deployed configuration with wheels engaging the floor surface in the decoupled configuration.