Invention Grant
- Patent Title: Method for using small molecule compounds to induce human tumor cells to be directly reprogrammed into non-oncogenic cells
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Application No.: US15780398Application Date: 2016-11-30
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Publication No.: US10463641B2Publication Date: 2019-11-05
- Inventor: Pei-Lin Zhang , Hong-Yang Wang
- Applicant: Transcend Cytotherapy Co., Ltd
- Applicant Address: CN Jiangsu
- Assignee: Transcend Cytotherapy Co., Ltd
- Current Assignee: Transcend Cytotherapy Co., Ltd
- Current Assignee Address: CN Jiangsu
- Agency: Banner & Witcoff, Ltd.
- Priority: CN201510869117 20151201
- International Application: PCT/CN2016/107910 WO 20161130
- International Announcement: WO2017/092663 WO 20170608
- Main IPC: A61K31/203
- IPC: A61K31/203 ; A61K45/06 ; A61K31/443 ; A61K31/4725 ; A61K31/506 ; A61K31/519 ; A61P35/00 ; C12N5/09
Abstract:
The disclosure includes a method of inducing direct reprogramming (transdifferentiation) into non-oncogenic cells accompanied by tumor cell apoptosis in human tumor cells using a small molecule composition, based on the mechanism of chemical-induction of direct cellular reprogramming. The disclosure also includes a small molecule composition used for the method, and culture media and agents prepared from the composition.
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