Invention Grant
- Patent Title: Non-gelatin vaccine protectant composition and live attenuated influenza vaccine
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Application No.: US15578124Application Date: 2016-04-26
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Publication No.: US10463741B2Publication Date: 2019-11-05
- Inventor: Zhenwei Shen , Xiaohui Chen , Fei Xu , Yao Sun , Xiaogeng Cheng , Changlin Zhu , Chunlai Jiang , Wei Kong
- Applicant: Changchun BCHT Biotechnology Co.
- Applicant Address: CN Changchun
- Assignee: Changchun BCHT Biotechnology Co.
- Current Assignee: Changchun BCHT Biotechnology Co.
- Current Assignee Address: CN Changchun
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: CN201510296497 20150602
- International Application: PCT/CN2016/080226 WO 20160426
- International Announcement: WO2016/192487 WO 20161208
- Main IPC: A61K47/42
- IPC: A61K47/42 ; A61K39/145 ; A61K47/12 ; A61K47/16 ; A61K47/18 ; A61K47/22 ; A61K47/26 ; A61K39/12 ; A61K9/00 ; A61K9/08 ; A61K39/00

Abstract:
The present invention provides a composition for use as the protectant for a live attenuated influenza virus vaccine, comprising the following components at the following concentrations: human serum albumin: 1.0-15.0 g/L, sugar: 15.0-95.0 g/L, and sodium glutamate: 0.5-15.0 g/L. The present invention also provides a process for preparing a live attenuated influenza vaccine with the composition according to the present invention, comprising the following steps: dissolving the components of the composition according to the present invention sequentially into a pH buffer solution, adjusting the pH to a specified value, performing filtration sterilization, and adding virus stock to give the live attenuated influenza vaccine. The present invention further provides a live attenuated influenza vaccine, which may be used as an injection or nasal spray.
Public/Granted literature
- US20180154004A1 Non-Gelatin Vaccine Protectant Composition and Live Attenuated Influenza Vaccine Public/Granted day:2018-06-07
Information query
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