A portable, self-contained, temperature-controlled enclosure capable of maintaining a constant, user-specified temperature within the enclosure independent of the outside environment. The device is ideal for the transport of material that is highly temperature sensitive and requires a stable temperature environment. The portable enclosure includes capability of cellular and GPS location beacon identification, comprehensive internal status and operation monitoring, and wireless communication capability of the device status, temperature and humidity parameters, and location using BLUE TOOTH, WIFI and/or cellular technology. The system is powered by an onboard rechargeable battery, external DC power, or external AC power.