Invention Grant
- Patent Title: Variants of adrenomedullin and calcitonin gene-related peptide and methods of use
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Application No.: US15568129Application Date: 2016-05-13
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Publication No.: US10464983B2Publication Date: 2019-11-05
- Inventor: Augen A. Pioszak
- Applicant: The Board of Regents of the University of Oklahoma
- Applicant Address: US OK Norman
- Assignee: The Board of Regents of the University of Oklahoma
- Current Assignee: The Board of Regents of the University of Oklahoma
- Current Assignee Address: US OK Norman
- Agency: Dunlap Codding, P.C.
- International Application: PCT/US2016/032444 WO 20160513
- International Announcement: WO2016/183479 WO 20161117
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/585 ; C07K14/575
Abstract:
Variant peptides of calcitonin gene-related peptide alpha (αCGRP), calcitonin gene-related peptide beta (βCGRP), and adrenomedullin (AM) are disclosed, wherein the variant peptides have high binding affinity and agonistic or antagonistic activity for at least one receptor complex of CLR:RAMP1, CLR:RAMP2, and CLR:RAMP3. Also disclosed are methods of use of the variant peptides in therapeutic treatments.
Public/Granted literature
- US20180141989A1 Variants of Adrenomedullin and Calcitonin Gene-Related Peptide and Methods of Use Public/Granted day:2018-05-24
Information query
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