Invention Grant
- Patent Title: Modulation of alternative MDM2 splicing
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Application No.: US15594054Application Date: 2017-05-12
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Publication No.: US10465193B2Publication Date: 2019-11-05
- Inventor: Dawn Suzan Chandler , Daniel Forrest Comiskey, Jr.
- Applicant: Research Institute at Nationwide Children's Hospital
- Applicant Address: US OH Columbus
- Assignee: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
- Current Assignee: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
- Current Assignee Address: US OH Columbus
- Agency: Benesch, Friedlander, Coplan & Aronoff LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113 ; A61K31/7088 ; A61K31/713
Abstract:
Compositions and methods for treating cancer in a subject in need thereof are described that includes administering a therapeutically effective amount of an oligonucleotide that inhibits the binding of splicing regulator SRSF1 or SRSF2 to MDM2 exon 4 or 11.
Public/Granted literature
- US20170355993A1 MODULATION OF ALTERNATIVE MDM2 SPLICING Public/Granted day:2017-12-14
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