Invention Grant
- Patent Title: Selective oxidation of 5-methylcytosine by TET-family proteins
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Application No.: US16169801Application Date: 2018-10-24
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Publication No.: US10465234B2Publication Date: 2019-11-05
- Inventor: Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
- Applicant: The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
- Applicant Address: US MA Boston US MD Bethesda
- Assignee: CHILDREN'S MEDICAL CENTER CORPORATION,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee: CHILDREN'S MEDICAL CENTER CORPORATION,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee Address: US MA Boston US MD Bethesda
- Agency: Nixon Peabody LLP
- Agent Mark J. FitzGerald
- Main IPC: C12Q1/26
- IPC: C12Q1/26 ; C12Q1/6827 ; G01N33/50 ; C12N9/02 ; G01N33/53 ; C12N5/00 ; C12Q1/6806 ; C12N5/074 ; G01N33/574 ; C12N5/0783 ; C12N15/873 ; C12Q1/6869 ; C12Q1/6886
Abstract:
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
Public/Granted literature
- US20190048405A1 SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS Public/Granted day:2019-02-14
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