A compression-ignited, opposed-piston engine equipped for multi-fuel operation includes at least one cylinder, a pair of pistons slidably disposed in the cylinder for opposing movement between respective bottom and fop center locations, and spaced-apart intake and exhaust ports near respective ends of the cylinder. The pistons include end surfaces constructed to form a shaped combustion chamber when the pistons are near top center locations during a compression stroke of the engine. At least one gaseous fuel injector communicates with the bore of the cylinder through an injector site in the cylinder between the intake port and the exhaust port. At least one liquid fuel injector communicates with the bore through an injector site in the cylinder. A fuel injection system coupled to the at least one gaseous fuel injector and to the at least one liquid fuel injector is operable to cause the at least one gaseous fuel injector to inject a main charge of gaseous fuel when the pistons are between the bottom and top center locations and to cause the at least one liquid fuel injector to inject a pilot charge of liquid fuel.