Systems and methods for acquiring magnetic resonance fingerprinting (MRF) data includes performing a schedule optimization that sequentially selects discrimination at each trajectory to yield an optimal trajectory and controlling a magnetic resonance imaging (MRI) system to perform a pulse sequence using the optimal trajectory to acquire MRF data. The process also includes estimating quantitative parameters of the subject using the MRF data by comparing the MRF data to a dictionary database and generating a map of quantitative parameters of the subject using the estimated quantitative parameters of the subject and the MRF data.