• Patent Title: Quantitative [Fe]-MRI (femri) of anti-PSMA-conjugated SPIONs based on PSMA expression levels
  • Application No.: US15574431
    Application Date: 2016-05-13
  • Publication No.: US10466326B2
    Publication Date: 2019-11-05
  • Inventor: Laurel Sillerud
  • Applicant: STC.UNM
  • Applicant Address: US NM Albuquerque
  • Assignee: STC. UNM
  • Current Assignee: STC. UNM
  • Current Assignee Address: US NM Albuquerque
  • Agency: Keith Vogt, Ltd.
  • Agent Keith A. Vogt
  • International Application: PCT/US2016/032489 WO 20160513
  • International Announcement: WO2016/187052 WO 20161124
  • Main IPC: G01R33/56
  • IPC: G01R33/56 G01R33/465 B82Y15/00 G06T7/00
Quantitative [Fe]-MRI (femri) of anti-PSMA-conjugated SPIONs based on PSMA expression levels
Abstract:
A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.
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