Systems and methods for dynamic and adaptive interrupt coalescing are disclosed. NVM Express (NVMe) implements a paired submission queue and completion queue mechanism, with host software on the host device placing commands into the submission queue. The memory device notifies the host device, via an interrupt, of entries on the completion queue. However, excessive interrupts become a burden to the host device. In that regard, the memory device includes a dynamic and adaptive interrupt coalescing methodology according to one or more parameters including: the completion queue; the commands; the queue depth; latency; and memory device firmware settings. In this way, the memory device may reduce the number of interrupts while still notifying the host device in a timely manner.