A method, an information handling system (IHS) and a detection system for detecting tampering of memory contents. The method includes retrieving, via a board management controller (BMC), from a first memory device, a first hash associated with current first data such as a firmware image stored on the first memory device and retrieving, from a second memory device, a previously stored second hash associated with initial first data. The method further includes determining if the first hash and the second hash match. In response to the first hash and the second hash not matching, an error message is generated which indicates that the current first data of the first memory device has been tampered with. The error message is stored to an error log. The error message identifies the specific current first data and/or firmware image that has been tampered with. The method repeats periodically during runtime.