Described herein are systems, methods, and software to enhance gateway security for multiple communication groups. In one implementation, a method of operating a gateway service includes identifying a data packet received from a first computing system, wherein the data packet comprises a first destination port value. The method further includes, identifying a group identifier within the data packet, wherein the group identifier associated with a communication group of the plurality of communication groups, translating the first destination port value to a second destination port value based on the group identifier, and forwarding the data packet with the translated second destination port value.