A span of responsibility access control system for use in plant process management and similar applications. The system leverages span-of-responsibility enabled user accounts and corresponding resource properties to assign, verify, and control access to assets and other resources in the plant process management system on a per user basis. Aspects of the system include configuration of properties for each monitored or controlled asset and association of a span of responsibility based on asset properties, such as asset type and location, with a user account. An access control module compares asset properties to the span of responsibility associated with the user account to determine whether the user is entitled to access any given asset, independent of determining permissions to act on such asset.