Systems, methods, and apparatus for commercial satellite operations with secure enclave for payload operations are disclosed. In one or more embodiments, the disclosed method comprises generating, by a secure enclave of a host satellite operation center (SOC), hosted commands according to service specifications for at least one hosted user. The method further comprises generating, by a SOC operation portion of the host SOC, host commands according to service specifications for a host user. Also, the method comprises transmitting, by the host SOC, the host commands and the hosted commands to a vehicle. In addition, the method comprises reconfiguring a host/hosted payload on the vehicle according to the host commands and the hosted commands. Additionally, the method comprises generating, by the host/hosted payload, host telemetry and hosted telemetry. Also, the method comprises transmitting, by the vehicle, the host telemetry and the hosted telemetry to the host SOC.