A method for determining a three-dimensional image data set from a plurality of two-dimensional projection images of an object under examination applies at least one morphological operation to each projection image in order to provide a processing image associated with the respective projection image. At least one respective imaging segment is segmented, in which a highly absorbent region is mapped, depending on the associated processing image, and a respective mask image is generated in which pixels belonging to the imaging segment are marked. An associated synthetic image for each projection image is determined, the image data of which within the imaging segment is set to predetermined values. The projection images and the synthetic images are separately filtered. The three-dimensional image data set is determined by backprojecting the mask images to determine a mask value for each voxel of the image data set.