Invention Grant
- Patent Title: Stable IGG4 based binding agent formulations
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Application No.: US15416289Application Date: 2017-01-26
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Publication No.: US10525130B2Publication Date: 2020-01-07
- Inventor: Julia Schnieders , Dirk Usener , Sabrina Ruggeberg , Ahmed Youssef , Martina Kirsch , Annika Hagendorf
- Applicant: Sanofi
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: FR1351013 20130206
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; A61K9/19 ; A61K47/12 ; A61K47/22 ; A61K47/26

Abstract:
The present invention provides stable pharmaceutical antibody formulations, including liquid drug product formulations and lyophilized drug product formulations, comprising an IgG4 binding agent and a citrate buffer, wherein the pH of the formulation is at or below both pH 6 and the pI of the binding agent. The formulations can be used in the treatment of chronic bowel diseases or rheumatoid arthritis.
Public/Granted literature
- US20170232104A1 STABLE IGG4 BASED BINDING AGENT FORMULATIONS Public/Granted day:2017-08-17
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