Invention Grant
- Patent Title: Selective targeting of an anti-inflammatory receptor in human mitochondria and preservation of mitochondrial functions
-
Application No.: US15525435Application Date: 2015-11-10
-
Publication No.: US10525144B2Publication Date: 2020-01-07
- Inventor: Honggang Cui , Peter M. Abadir , Jeremy D. Walston , Andrew G. Cheetham
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- International Application: PCT/US2015/059899 WO 20151110
- International Announcement: WO2016/077311 WO 20160519
- Main IPC: A61K47/64
- IPC: A61K47/64 ; A61K47/65 ; A61K49/18 ; A61K49/00 ; A61K31/41 ; A61K31/4178 ; A61K31/4184 ; A61K31/4245
Abstract:
The present invention provides compounds and a method for the targeted delivery of Mitochondrial Angiotensin Receptor Blockers (MARBs) to the Mitochondrial Angiotensin System (MAS) for the treatment of diseases caused by angiotensin-related mitochondrial dysfunction. The compounds include a mitochondrial targeting signal, a residue of a drug molecule, a functional moiety, and a scaffold moiety.
Public/Granted literature
Information query
IPC分类:
