A composite material for a pharmaceutical packaging is provided that includes a substrate and a protective layer. The substrate has a contact region in contact with the protective layer. The contact region includes a contact area between the substrate and the protective layer and a region of the substrate close to the surface. The substrate is made of glass or of a cyclic olefin polymer or a cyclic olefin copolymer, while the protective layer is made of ceramic material. The substrate in the contact region is different from the substrate outside the contact region.