A combination structure of a hub and spokes is provided, including: a hub shell, having separate small and large flanges, the small and large flanges having first and second assembling holes, respectively; a plurality of first spokes, assembled to one of the first assembling holes and a wheel rim; a plurality of second spokes, including cylindrical spokes and aero bladed spokes, the cylindrical spokes and aero bladed spokes being alternatively assembled to the second assembling holes and to the wheel rim; as viewed along an axial direction of the hub shell, every two of the second spokes which are neighboring to each other intersect with each other to define an intersecting area, each first spoke extends and passes through one of the intersecting areas.