An in-vehicle locking safe system comprising a lockbox having one or more walls defining an enclosure, wherein the lockbox is configured with one or more apertures in one or more lockbox walls. The in-vehicle locking safe system further comprises a vehicle structural element including one or more studs configured to be inserted within one or more apertures in one or more lockbox walls, and a fastener component coupled to a portion of the one or more studs at a location inside the enclosure of the lockbox. In some embodiments, the vehicle structural element includes one or more of a vehicle chassis, a slider rail, a slider track, and/or a floor layer.