Invention Grant
- Patent Title: Prodrugs of dithiol mucolytic agents
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Application No.: US15144288Application Date: 2016-05-02
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Publication No.: US10526283B2Publication Date: 2020-01-07
- Inventor: Michael Ross Johnson , William R. Thelin
- Applicant: PARION SCIENCES, INC.
- Applicant Address: US NC Durham
- Assignee: PARION SCIENCES, INC.
- Current Assignee: PARION SCIENCES, INC.
- Current Assignee Address: US NC Durham
- Agency: Cooley LLP
- Main IPC: A61K31/265
- IPC: A61K31/265 ; C07C327/36 ; C07C327/28 ; C07C327/22 ; C07C323/16 ; C12P19/60 ; C12N9/02 ; C12N9/10 ; C12P17/16 ; A61K9/00 ; A61K9/16 ; A61K31/047 ; A61K31/133 ; A61K31/341 ; A61K31/385 ; A61K31/683 ; A61K33/14 ; C07D307/68 ; C07D339/00 ; C07D339/08 ; C07F9/6578 ; C07C321/20 ; C07D241/12 ; C07C329/12 ; C07D307/64
Abstract:
Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (Ia)-(Ib): where the structural variables are as defined herein.
Public/Granted literature
- US20160318861A1 NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS Public/Granted day:2016-11-03
Information query
