Invention Grant
- Patent Title: Method for preparing 4-(piperidin-4-yl)morpholine
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Application No.: US16308312Application Date: 2017-06-09
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Publication No.: US10526288B2Publication Date: 2020-01-07
- Inventor: Hiromi Ishikawa , Kiyono Nakagawa , Yukiko Takeda
- Applicant: YUKI GOSEI KOGYO CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: YUKI GOSEI KOGYO CO., LTD.
- Current Assignee: YUKI GOSEI KOGYO CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Priority: JP2016-115040 20160609
- International Application: PCT/JP2017/021419 WO 20170609
- International Announcement: WO2017/213245 WO 20171214
- Main IPC: C07D211/72
- IPC: C07D211/72 ; C07D265/30 ; C07D413/04 ; C07D211/58 ; C07B61/00
Abstract:
The object of the present invention is to provide a method for preparing 4-(piperidin-4-yl)morpholine, which is easy to operate. The object can be solved by a method for preparing 4-(1-benzylpiperidin-4-yl)morpholine, characterized in that 5-fold molar or more of morpholine is added to 1-benzyl-4-piperidone, and the mixture is reacted with hydrogen under 1 MPa or less in the presence of platinum catalyst or palladium catalyst.
Public/Granted literature
- US20190210968A1 METHOD FOR PREPARING 4-(PIPERIDIN-4-YL)MORPHOLINE Public/Granted day:2019-07-11
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