Invention Grant
- Patent Title: Potent dual BRD4-kinase inhibitors as cancer therapeutics
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Application No.: US16166611Application Date: 2018-10-22
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Publication No.: US10526291B2Publication Date: 2020-01-07
- Inventor: Ernst Schönbrunn , Nicholas J. Lawrence , Harshani R. Lawrence , Gary W. Reuther
- Applicant: H. Lee Moffitt Cancer Center and Research Institute, Inc.
- Applicant Address: US FL Tampa
- Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
- Current Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
- Current Assignee Address: US FL Tampa
- Agency: Meunier Carlin & Curfman LLC
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D239/48 ; C07D403/12 ; C07D401/12 ; C07D405/12 ; C07D239/70 ; C07D239/95 ; C07D491/048 ; A61K31/505 ; A61K31/506 ; A61K31/517 ; A61K31/519 ; A61K31/5377 ; A61K45/06
Abstract:
Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
Public/Granted literature
- US20190055203A1 POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS Public/Granted day:2019-02-21
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