Synthetic route to 2′-deoxy-2′,2′-difluorotetrahydrouridines

Invention Grant

US10526362B2 Synthetic route to 2′-deoxy-2′,2′-difluorotetrahydrouridines 有权

Patent Title: Synthetic route to 2′-deoxy-2′,2′-difluorotetrahydrouridines
Application No.: US15813743

Application Date: 2017-11-15
Publication No.: US10526362B2

Publication Date: 2020-01-07
Inventor: Hyeong-wook Choi , Steven Mathieu , Frank Fang , Bryan Matthew Lewis
Applicant: Otsuka Pharmaceutical Co., Ltd.
Applicant Address: JP Tokyo
Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
Current Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
Current Assignee Address: JP Tokyo
Agency: Myers Bigel, P.A.
Main IPC: C07H19/00
IPC: C07H19/00 ; C07H19/06 ; C07H1/00 ; C07H19/04 ; C07B57/00 ; C07H1/06 ; C07H17/02

Abstract:

The present invention relates to methods and intermediates for synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine compounds.

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IPC分类:

C	化学；冶金
C07	有机化学
C07H	糖类；及其衍生物；核苷；核苷酸；核酸（糖醛酸或糖质酸的衍生物入C07C、C07D；糖醛酸、糖质酸入C07C59/105，C07C59/285；氰醇类入C07C255/16；烯糖类入C07D；未知结构的化合物入C07G；多糖类，有关的衍生物入C08B；有关基因工程的DNA或RNA，载体，例如质粒，或它们的分离、制备或纯化入C12N15/00；制糖工业入C13）
C07H19/00	含有杂环与糖化物基团共有1个杂环原子的化合物；核苷；单核苷酸类；及其脱水衍生物