Invention Grant
- Patent Title: Human monoclonal antibodies fragments inhibiting both the Cath-D catalytic activity and its binding to the LRP1 receptor
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Application No.: US15574515Application Date: 2016-05-20
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Publication No.: US10526415B2Publication Date: 2020-01-07
- Inventor: Emmanuelle Liaudet-Coopman , Thierry Chardes , Pierre Martineau , Yahya Ashraf
- Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE MONTPELLIER , INSTITUT REGIONAL DU CANCER DE MONTPELLIER
- Applicant Address: FR Paris FR Montpellier FR Montpellier
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITE DE MONTPELLIER,INSTITUT REGIONAL DU CANCER DE MONTPELLIER
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITE DE MONTPELLIER,INSTITUT REGIONAL DU CANCER DE MONTPELLIER
- Current Assignee Address: FR Paris FR Montpellier FR Montpellier
- Agency: W&C IP
- Priority: EP15305775 20150522
- International Application: PCT/EP2016/061454 WO 20160520
- International Announcement: WO2016/188911 WO 20161201
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/30 ; A61P35/00 ; C07K16/40 ; A61K39/00
Abstract:
The invention relates to human anti-Cath-D neutralizing monoclonal antibodies and uses thereof. More particularly, the invention relates to an isolated human monoclonal antibody or a fragment thereof comprising a heavy chain variable region comprising SEQ ID NO: 2 in the H-CDR1 region, SEQ ID NO: 3 in the H-CDR2 region and SEQ ID NO: 4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO: 7 in the L-CDR2 region and SEQ ID NO: 8 in the L-CDR3 region. The invention also relates to an isolated human monoclonal antibody or a fragment thereof comprising a heavy chain variable region comprising SEQ ID NO: 10 in the H-CDR1 region, SEQ ID NO: 11 in the H-CDR2 region and SEQ ID NO: 12 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 14 in the L-CDR1 region, SEQ ID NO: 15 in the L-CDR2 region and SEQ ID NO: 16 in the L-CDR3 region.
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