Invention Grant
- Patent Title: Modulators of ACYL-COA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
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Application No.: US15651758Application Date: 2017-07-17
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Publication No.: US10526418B2Publication Date: 2020-01-07
- Inventor: Yuguang Shi
- Applicant: The Penn State Research Foundation
- Applicant Address: US PA University Park
- Assignee: The Penn State Research Foundation
- Current Assignee: The Penn State Research Foundation
- Current Assignee Address: US PA University Park
- Agency: McHale & Slavin, P.A.
- Main IPC: C07K16/40
- IPC: C07K16/40 ; A61K38/17 ; A61K38/46 ; A61K39/395 ; C12N15/113 ; C12Q1/6883 ; A61K39/00
Abstract:
Compositions of modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.
Public/Granted literature
- US20170320964A1 Modulators of ACYL-COA Lysocardiolipin Acyltransferase 1 (ALCAT1) and Uses Thereof Public/Granted day:2017-11-09
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