Invention Grant
- Patent Title: Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
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Application No.: US15789419Application Date: 2017-10-20
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Publication No.: US10526649B2Publication Date: 2020-01-07
- Inventor: Fei Chen , Shahar Alon , Andrew Payne , Asmamaw Wassie , Daniel Goodwin , Edward Stuart Boyden , Evan Daugharthy , Jonathan Scheiman
- Applicant: Massachusetts Institute of Technology , President and Fellows of Harvard College
- Applicant Address: US MA Cambridge US MA Cambridge
- Assignee: Massachusetts Institute of Technology,President and Fellows of Harvard College
- Current Assignee: Massachusetts Institute of Technology,President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge US MA Cambridge
- Agency: Elmore Patent Law Group, P.C.
- Agent Joseph Zucchero; Carolyn Elmore
- Main IPC: C12Q1/6874
- IPC: C12Q1/6874 ; C12Q1/6841
Abstract:
The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ sequencing of nucleic acids in a process referred to herein as “expansion sequencing” (ExSEQ).
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