Invention Grant
- Patent Title: Modulators of alpha-synuclein toxicity
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Application No.: US13745052Application Date: 2013-01-18
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Publication No.: US10526651B2Publication Date: 2020-01-07
- Inventor: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
- Applicant: Whitehead Institute for Biomedical Research , The Curators of the University of Missouri
- Applicant Address: US MA Cambridge US MO Columbia
- Assignee: Whitehead Institute for Biomedical Research,The Curators of the University of Missouri
- Current Assignee: Whitehead Institute for Biomedical Research,The Curators of the University of Missouri
- Current Assignee Address: US MA Cambridge US MO Columbia
- Agency: Fish & Richardson P.C.
- Main IPC: C12Q1/6876
- IPC: C12Q1/6876 ; G01N33/50
Abstract:
Disclosed are compositions and methods for modulating expression of genes that function at the step of ER to Golgi trafficking. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Public/Granted literature
- US20130244903A1 MODULATORS OF ALPHA-SYNUCLEIN TOXICITY Public/Granted day:2013-09-19
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