The present disclosure provides an isolation and restoration method for compound contaminated soil. The isolation and restoration method for the compound contaminated soil provided by the present disclosure is used for isolation and restoration of a contaminated site, which includes: laying an isolation layer, a pure soil layer and an arable soil layer containing compound soil in turn on the contaminated site which is flattened and compacted, where the compound soil is composed of loess, slaked lime, fine sand and substances having an adsorption function in a volume ratio.