Control system to prevent wind turbine misalignment situations employing mathematical algorithms implemented in the wind turbine controller. Different optimization algorithms have been analyzed getting results that yaw the nacelle of the wind turbine to positions that would maximize the efficiency function. Control system for detecting and preventing wind turbine misalignment situations that comprises a parameters acquisition unit that relates the wind direction with the deviation of the wind turbine nacelle, a wind turbine efficiency function calculation unit and a deviation comparison unit of the nacelle.