A heat exchange assembly in an air to air heat exchanger includes an arrangement, construction, and/or configuration of a combination of latent heat exchangers and sensible heat exchangers. The heat exchange assembly can minimize footprint required for the air to air heat exchanger, e.g. air handler, by avoiding the need for block offs and plenums, can support direct mounting of a bypass damper(s), can provide acceptable pressure drop ratings and provide good heat exchange efficiency and energy recovery performance. The arrangement and configuration of the sensible heat exchangers and latent heat exchangers of the heat exchange assembly have condensate management for example to provide frost protection.