Mechanisms are provided for communicating with a patient. The mechanisms generate a patient registry comprising a plurality of patient registry records, each patient registry record being associated with a corresponding patient and comprising personal and medical information about the corresponding patient. The mechanisms collect, for each patient registry record, first data regarding treatment of the corresponding patient and second data regarding communications made with the corresponding patient. The mechanisms determine, based on analysis of the first data and second data associated with each of the patient registry records, a mode of communication that is most likely to result in a successful treatment of patients. The mechanisms initiate a communication with a patient of interest using the determined mode of communication based on the results of the determination.