Integrated circuits and methods for fabricating integrated circuits are provided. An exemplary method for fabricating an integrated circuit includes providing a substrate including a semiconductor layer over an insulator layer. The method includes selectively replacing portions of the semiconductor layer with insulator material to define an isolated semiconductor layer region. Further, the method includes selectively forming a relaxed layer on the isolated semiconductor layer region. Also, the method includes selectively forming a strained layer on the relaxed layer. The method forms a device over the strained layer.