Embodiments of the disclosure relate to calibrating a power amplifier. The power amplifier calibration circuit is configured to provide a plurality of bias signal combinations each including a respective first bias signal and a respective second bias signal to the power amplifier. Power amplifier performance parameters for each of the bias signal combinations can be measured and provided to a control circuit in the power amplifier calibration circuit. The control circuit is configured to rank the measured power amplifier performance parameters based on predefined ranking criteria and determines a selected bias signal combination that can optimize the power amplifier performance parameters of the power amplifier. As such, it is possible to calibrate the power amplifier to operate at a balanced performance level, thus helping to improve radio frequency (RF) coverage and performance of the remote unit in a wireless distribution system (WDS).