Systems and methods are disclosed herein that relate wireless device positioning based on cell portion specific Positioning Reference Signals (PRSs) by multiple Transmit Points (TPs) in a shared cell. In some embodiments, a method of operation of a TP in a cellular communications network is provided. The TP is one of multiple of non-co-located TPs of a shared cell that has a shared cell identifier. The method of operation of the TP comprises transmitting a PRS having at least one parameter that is a function of a cell portion identifier of the TP, where the at least one parameter comprises a frequency-shift of the PRS, a portion of a system bandwidth in which the PRS is transmitted, and/or a PRS sequence used for the PRS. By transmitting cell-portion-specific PRSs, the TPs in the shared cell enable wireless device positioning based on PRSs transmitted by the non-co-located TPs.