The present technology is concerned with a solid-state imaging device, a method of driving a solid-state imaging device, and an electronic device which are capable of reducing power supply noise of a pixel signal with a single-ended circuit arrangement.The solid-state imaging device includes a pixel section including a plurality of unit pixels disposed for photoelectric transduction, a power supply noise detector detecting a noise component from a power supply used to energize the unit pixels and outputting a single-ended canceling signal including a canceling component for canceling the noise component, a sample and hold section configured to sample single-ended pixel signals output from the unit pixels and hold and output pixel signals representing the sampled pixel signals from which the noise component has been removed on the basis of the canceling signal, and an A/D converter performing A/D conversion on the pixel signals that have been held. The present technology is applicable to a CMOS image sensor, for example.